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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteronegel in terms of changes in serum hormones, which measured androgen and sex hormone levels. They were split into 2 groups by sex and age between 30-61 and 60 years or older at the start of the study (n=33) and then followed for an average of 8.6 years and 9.6 years. A total of 973 men were randomly assigned to weigh in at the start of the study (n=8) and have their testosterone level measured at a single visits (n=25). The placebo group received weight loss medication (pills, ointments, gels, tablets and suppositories). The other groups received testosterone enanthate gel, testosterone injection and placebo medication alone, with an average of 24.4 years between randomisation. The men who had received Weight Watchers intervention had lost an average of 2.6kg (7.6ins) in the weight reduction programme and an average of 5.7 ins (15ins) in the testosterone gel group (P < 0.0001), while the weight loss group had lost an average 2.1kg (7.4ins) in the Weight Watchers intervention and a median (IQR) 5.2ins (14ins) in the testosterone gel group (P < 0.0001). The differences between the weight loss and the trial on testosterone were significant (P (value) = 0.02), with a mean gain of 3.7 (7.1)ng/ml compared with a mean reduction of 2.2 (5.0)ng/ml in the testosterone group, with no change in the placebo group (P = 0.39). 'Treatment with testosterone gel did improve serum testosterone levels,' said Dr Fung. 'However, the group that received testosterone gel had significantly higher changes in the serum testosterone concentration. 'To my knowledge, this is the first study that has investigated the effects of treatment with testosterone gel in relation to changes in serum concentrations of sex hormones.' Dr Fung concludes that the results confirm what was seen in previous smaller trials. 'These findings are important in determining the best approach to use when choosing a weight loss therapy to encourage individuals to lose weight,' adds Dr Hwang. 'For instance, they can lead to improved weight loss maintenance following weight loss treatment when compared with no treatment. We can also hope to use this information to inform the development of the next generation of testosterone delivery therapies.' Reference: Related Article: